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Correction of a splice-site mutation in the beta-globin gene stimulated by triplex-forming peptide nucleic acids
Splice-site mutations in the beta-globin gene can lead to aberrant transcripts and decreased functional beta-globin, causing beta-thalassemia. Triplex-forming DNA oligonucleotides (TFOs) and peptide nucleic acids (PNAs) have been shown to stimulate recombination in reporter gene loci in mammalian ce...
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| Main Authors: | , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2533221/ https://ncbi.nlm.nih.gov/pubmed/18757759 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711793105 |
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