Transplantation of a tyrosine editing domain into a tyrosyl-tRNA synthetase variant enhances its specificity for a tyrosine analog

To guarantee specific tRNA and amino acid pairing, several aminoacyl-tRNA synthetases correct aminoacylation errors by deacylating or “editing” misaminoacylated tRNA. A previously developed variant of Escherichia coli tyrosyl-tRNA synthetase (iodoTyrRS) esterifies or “charges” tRNA(Tyr) with a nonna...

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Main Authors: Oki, Kenji, Sakamoto, Kensaku, Kobayashi, Takatsugu, Sasaki, Hiroshi M., Yokoyama, Shigeyuki
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2008
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533184/
https://ncbi.nlm.nih.gov/pubmed/18765802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803531105
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