Transplantation of a tyrosine editing domain into a tyrosyl-tRNA synthetase variant enhances its specificity for a tyrosine analog

To guarantee specific tRNA and amino acid pairing, several aminoacyl-tRNA synthetases correct aminoacylation errors by deacylating or “editing” misaminoacylated tRNA. A previously developed variant of Escherichia coli tyrosyl-tRNA synthetase (iodoTyrRS) esterifies or “charges” tRNA(Tyr) with a nonna...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Oki, Kenji, Sakamoto, Kensaku, Kobayashi, Takatsugu, Sasaki, Hiroshi M., Yokoyama, Shigeyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533184/
https://ncbi.nlm.nih.gov/pubmed/18765802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803531105
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky