Separate cis-trans Pathways Post-transcriptionally Regulate Murine CD154 (CD40 Ligand) Expression: A NOVEL FUNCTION FOR CA REPEATS IN THE 3′-UNTRANSLATED REGION

We report a role for CA repeats in the 3′-untranslated region (3′-UTR) in regulating CD154 expression. Human CD154 is encoded by an unstable mRNA; this instability is conferred in cis by a portion of its 3′-UTR that includes a polypyrimidine-rich region and CA dinucleotide repeat. We demonstrate sim...

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Detalhes bibliográficos
Main Authors: Hamilton, B. JoNell, Wang, Xiao-Wei, Collins, Jane, Bloch, Donald, Bergeron, Alan, Henry, Brian, Terry, Benjamin M., Zan, Moe, Mouland, Andrew J., Rigby, William F. C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
RNA-Mediated Regulation and Noncoding Rnas
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533087/
https://ncbi.nlm.nih.gov/pubmed/18640985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802492200
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