Ca(2+)/Calmodulin-dependent Protein Kinase II-dependent Remodeling of Ca(2+) Current in Pressure Overload Heart Failure

Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) activity is increased in heart failure (HF), a syndrome characterized by markedly increased risk of arrhythmia. Activation of CaMKII increases peak L-type Ca(2+) current (I(Ca)) and slows I(Ca) inactivation. Whether these events are linked mecha...

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Detalhes bibliográficos
Main Authors: Wang, Yanggan, Tandan, Samvit, Cheng, Jun, Yang, Chunmei, Nguyen, Lan, Sugianto, Jessica, Johnstone, Janet L., Sun, Yuyang, Hill, Joseph A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533065/
https://ncbi.nlm.nih.gov/pubmed/18622016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803043200
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