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Deletional Tolerance Mediated by Extrathymic Aire-Expressing Cells
The prevention of autoimmunity requires elimination of self-reactive T cells during their development and maturation. Expression of diverse self-antigens by stromal cells in the thymus is essential to this process, and depends, in part, on the activity of the Autoimmune Regulator (Aire) gene. Here w...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2532844/ https://ncbi.nlm.nih.gov/pubmed/18687966 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1159407 |
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