Retrovirally induced CTL degranulation mediated by IL-15 expression and infection of mononuclear phagocytes in patients with HTLV-I–associated neurologic disease

CD8(+) T cells contribute to central nervous system inflammation in human T-cell lymphotropic virus type I (HTLV-I)–associated myelopathy/tropical spastic paraparesis (HAM/TSP). We analyzed CD8(+) T-cell dysfunction (degranulation and IFN-γ production) and have demonstrated that CD8(+) T cells of pa...

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Detalhes bibliográficos
Main Authors: Enose-Akahata, Yoshimi, Oh, Unsong, Grant, Christian, Jacobson, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2532810/
https://ncbi.nlm.nih.gov/pubmed/18509087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-02-138529
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