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Intronically encoded siRNAs improve dynamic range of mammalian gene regulation systems and toggle switch

Applications of conditional gene expression, whether for therapeutic or basic research purposes, are increasingly requiring mammalian gene control systems that exhibit far tighter control properties. While numerous approaches have been used to improve the widely used Tet-regulatory system, many appl...

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Bibliographic Details
Main Authors: Greber, David, El-Baba, Marie Daoud, Fussenegger, Martin
Format: Artigo
Language:Inglês
Published: Oxford University Press 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2532736/
https://ncbi.nlm.nih.gov/pubmed/18632760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn443
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