Detection of Adriamycin–DNA adducts by accelerator mass spectrometry at clinically relevant Adriamycin concentrations

Limited sensitivity of existing assays has prevented investigation of whether Adriamycin–DNA adducts are involved in the anti-tumour potential of Adriamycin. Previous detection has achieved a sensitivity of a few Adriamycin–DNA adducts/10(4) bp DNA, but has required the use of supra-clinical drug co...

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Bibliographic Details
Main Authors: Coldwell, Kate E., Cutts, Suzanne M., Ognibene, Ted J., Henderson, Paul T., Phillips, Don R.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2008
Subjects:
Methods Online
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2532723/
https://ncbi.nlm.nih.gov/pubmed/18632763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn439
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