Acyl-CoA synthetase activity links wild-type but not mutant α-synuclein to brain arachidonate metabolism

Because α-synuclein (Snca) has a role in brain lipid metabolism, we determined the impact that the loss of α-synuclein had on brain arachidonic acid (20:4n-6) metabolism in vivo using Snca(-/-) mice. We measured [1-(14)C]20:4n-6 incorporation and turnover kinetics in brain phospholipids using an est...

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Detalhes bibliográficos
Main Authors: Golovko, Mikhail Y., Rosenberger, Thad A., Faergeman, Nils J., Feddersen, Søren, Cole, Nelson B., Pribill, Ingrid, Berger, Johannes, Nussbaum, Robert L., Murphy, Eric J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2532510/
https://ncbi.nlm.nih.gov/pubmed/16734431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi0600289
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