Arachidonic acid downregulates acyl-CoA synthetase 4 expression by promoting its ubiquitination and proteasomal degradation

ACSL4 is a member of the long-chain acyl-CoA synthetase (ACSL) family with a marked preference for arachidonic acid (AA) as its substrate. Although an association between elevated levels of ACSL4 and hepatosteatosis has been reported, the function of ACSL4 in hepatic FA metabolism and the regulation...

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Hlavní autoři: Kan, Chin Fung Kelvin, Singh, Amar Bahadur, Stafforini, Diana M., Azhar, Salman, Liu, Jingwen
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2014
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109760/
https://ncbi.nlm.nih.gov/pubmed/24879802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M045971
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