[(11)C]Cyclopropyl-FLB 457: a PET radioligand for low densities of dopamine D(2) receptors

(S)-5-Bromo-N-[(1-cyclopropylmethyl-2-pyrrolidinyl)methyl]-2,3-dimethoxybenzamide (4) has pico-molar in vitro binding affinity to D(2) receptor (K(i)(D(2)) = 0.003 nM) with lower affinity to D(3) receptor (K(i) (D(3))= 0.22 nM). In this study, we describe radiosynthesis of [(11)C]4 and evaluation of...

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Autori principali: Airaksinen, Anu J., Nag, Sangram, Finnema, Sjoerd J., Mukherjee, Jogeshwar, Chattopadhyay, Sankha, Gulyás, Balázs, Farde, Lars, Halldin, Christer
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2531229/
https://ncbi.nlm.nih.gov/pubmed/18534857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.05.039
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