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Human polynucleotide phosphorylase reduces oxidative RNA damage and protects HeLa cell against oxidative stress

We examined HeLa cell viability and RNA oxidative damage in response to hydrogen peroxide (H(2)O(2)) treatment. The level of damaged RNA, measured by the content of 8-hydroxyguanosine (7,8-dihydro-8-oxoguanosine, 8-oxoG), increases depending on H(2)O(2) dosage and is inversely correlated with cell v...

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Detalles Bibliográficos
Main Authors: Wu, Jinhua, Li, Zhongwei
Formato: Artigo
Idioma:Inglês
Publicado: 2008
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2531134/
https://ncbi.nlm.nih.gov/pubmed/18501193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2008.05.058
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