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BCR/ABL and other kinases from chronic myeloproliferative disorders stimulate single-strand annealing, an unfaithful DNA double-strand break repair
Myeloproliferative disorders (MPDs) are stem cell-derived clonal diseases arising as a consequence of acquired aberrations in c-ABL, JAK2, and PDGFR, that generate oncogenic fusion tyrosine kinases (FTKs) including BCR/ABL, TEL/ABL, TEL/JAK2, and TEL/PDGFβR. Here we show that FTKs stimulate the form...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2531069/ https://ncbi.nlm.nih.gov/pubmed/18757400 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-1101 |
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