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The Synthesis of Highly Substituted Isoxazoles by Electrophilic Cyclization. An Efficient Synthesis of Valdecoxib

[Image: see text] A large number of functionally-substituted 2-alkyn-1-one O-methyl oximes have been cyclized under mild reaction conditions in the presence of ICl to give the corresponding 4-iodoisoxazoles in moderate to excellent yields. The resulting 4-iodoisoxazoles undergo various palladium-cat...

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Detalhes bibliográficos
Main Authors: Waldo, Jesse P., Larock, Richard C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529460/
https://ncbi.nlm.nih.gov/pubmed/17979295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo701942e
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