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Highly-Efficient Purification of Native Polyhistidine-tagged Proteins by Multivalent NTA-modified Magnetic Nanoparticles

A new bis-nitrilotriacetic acid (NTA) chelate with catechol anchor was synthesized and immobilized on superparamagnetic iron oxide nanoparticles. When loaded with Ni(II), these bis-NTA-immobilized nanoparticles were shown to bind polyhistidine (His×6-tagged) fusion proteins in their native, folded c...

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Bibliografski detalji
Glavni autori: Kim, Jason S., Valencia, C. Alexander, Liu, Rihe, Lin, Wenbin
Format: Artigo
Jezik:Inglês
Izdano: 2007
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529454/
https://ncbi.nlm.nih.gov/pubmed/17311440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc060195l
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