The absence of myristic acid decreases membrane binding of p60src but does not affect tyrosine protein kinase activity.
We have constructed two point mutants of Rous sarcoma virus in which the amino-terminal glycine residue of the transforming protein, p60src, was changed to an alanine or a glutamic acid residue. Both mutant proteins failed to become myristylated and, more importantly, no longer transformed cells. Th...
Kaydedildi:
| Yayımlandı: | J Virol |
|---|---|
| Asıl Yazarlar: | , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Microbiology (ASM)
1986
|
| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC252933/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3009860/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.58.2.468-474.1986 |
| Etiketler: |
Etiket eklenmemiş, İlk siz ekleyin!
|