An amphioxus orthologue of the estrogen receptor that does not bind estradiol: Insights into estrogen receptor evolution

BACKGROUND: The origin of nuclear receptors (NRs) and the question whether the ancestral NR was a liganded or an unliganded transcription factor has been recently debated. To obtain insight into the evolution of the ligand binding ability of estrogen receptors (ER), we comparatively characterized th...

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Main Authors: Paris, Mathilde, Pettersson, Katarina, Schubert, Michael, Bertrand, Stephanie, Pongratz, Ingemar, Escriva, Hector, Laudet, Vincent
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2008
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529310/
https://ncbi.nlm.nih.gov/pubmed/18655705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-8-219
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