Engineered recombinant human paraoxonase 1 (rHuPON1) purified from Escherichia coli protects against organophosphate poisoning

The high-density lipoprotein-associated enzyme paraoxonase 1 (PON1) hydrolyzes lactones, aromatic esters, and neurotoxic organophosphorus (OP) compounds, including insecticide metabolites and nerve agents. Experiments with mice lacking PON1 (PON1(−/−) mice) have established that plasma PON1 protects...

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Detaylı Bibliyografya
Asıl Yazarlar: Stevens, Richard C., Suzuki, Stephanie M., Cole, Toby B., Park, Sarah S., Richter, Rebecca J., Furlong, Clement E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2008
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529096/
https://ncbi.nlm.nih.gov/pubmed/18711144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805865105
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