Complex I within Oxidatively Stressed Bovine Heart Mitochondria Is Glutathionylated on Cys-531 and Cys-704 of the 75-kDa Subunit: POTENTIAL ROLE OF CYS RESIDUES IN DECREASING OXIDATIVE DAMAGE

Complex I has reactive thiols on its surface that interact with the mitochondrial glutathione pool and are implicated in oxidative damage in many pathologies. However, the Cys residues and the thiol modifications involved are not known. Here we investigate complex I thiol modification within oxidati...

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Detalhes bibliográficos
Main Authors: Hurd, Thomas R., Requejo, Raquel, Filipovska, Aleksandra, Brown, Stephanie, Prime, Tracy A., Robinson, Alan J., Fearnley, Ian M., Murphy, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Metabolism and Bioenergetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529008/
https://ncbi.nlm.nih.gov/pubmed/18611857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803432200
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