Synthesis, Anti-HIV Activity, and Metabolic Stability of New Alkenyldiarylmethane (ADAM) HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)

Non-nucleoside inhibitors of HIV-1 reverse transcriptase (NNRTIs) are part of the combination therapy currently used to treat HIV infection. Based on analogy with known HIV-1 NNRT inhibitors, eighteen novel alkenyldiarylmethanes (ADAMs) containing 5-chloro-2-methoxyphenyl, 3-cyanophenyl or 3-fluoro-...

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Hlavní autoři: Deng, Bo-Liang, Hartman, Tracy L., Buckheit, Robert W., Pannecouque, Christophe, De Clercq, Erik, Fanwick, Phillip E., Cushman, Mark
Médium: Artigo
Jazyk:Inglês
Vydáno: 2005
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2528834/
https://ncbi.nlm.nih.gov/pubmed/16162014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm050452s
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