Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells

BACKGROUND AND PURPOSE: GPR119 is a G protein-coupled receptor that is preferentially expressed in islet cells and mediates insulin secretion. Oleoyl-lysophosphatidylcholine and oleoylethanolamide (OEA) act as endogenous ligands for this receptor, whereas PSN375963 and PSN632408 are two recently rep...

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Detalhes bibliográficos
Main Authors: Ning, Y, O'Neill, K, Lan, H, Pang, L, Shan, L X, Hawes, B E, Hedrick, J A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2528830/
https://ncbi.nlm.nih.gov/pubmed/18724386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.337
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