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Molecular Architecture of DesI: A Key Enzyme in the Biosynthesis of Desosamine
Desosamine is a 3-(dimethylamino)-3,4,6-trideoxyhexose found, for example, in such macrolide antibiotics as erthyromycin, azithromycin, and clarithromycin. The efficacies of these macrolide antibiotics are markedly reduced in the absence of desosamine. In the bacterium, Streptomyces venezuelae, six...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2528198/ https://ncbi.nlm.nih.gov/pubmed/17630700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi700751d |
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