Poorer outcome in stromal HIF-2α- and CA9-positive colorectal adenocarcinomas is associated with wild-type TP53 but not with BNIP3 promoter hypermethylation or apoptosis

Stromal expression of hypoxia inducible factor 2α (HIF-2α) and carbonic anhydrase 9 (CA9) are associated with a poorer prognosis in colorectal cancer (CRC). Tumour cell death, regulated by a hypoxic stromal microenvironment, could be of importance in this respect. Therefore, we correlated apoptosis,...

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Bibliographic Details
Main Authors: Cleven, A H G, Wouters, B G, Schutte, B, Spiertz, A J G, van Engeland, M, de Bruïne, A P
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2008
Subjects:
Clinical Study
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2528150/
https://ncbi.nlm.nih.gov/pubmed/18728663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604547
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