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Binding Induced Folding in p53-MDM2 Complex
The MDM2 N-terminal domain can bind to the transactivation domain of p53 and downregulate its ability to activate transcription. It was found that binding with p53 stabilizes the MDM2 Nterminal domain. Thus the coupling between binding and folding is essential in the normal functional interactions b...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2528056/ https://ncbi.nlm.nih.gov/pubmed/17302414 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja0678774 |
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