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Phylogenetic profiles reveal evolutionary relationships within the “twilight zone” of sequence similarity

Inferring evolutionary relationships among highly divergent protein sequences is a daunting task. In particular, when pairwise sequence alignments between protein sequences fall <25% identity, the phylogenetic relationships among sequences cannot be estimated with statistical certainty. Here, we...

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Detalhes bibliográficos
Main Authors: Chang, Gue Su, Hong, Yoojin, Ko, Kyung Dae, Bhardwaj, Gaurav, Holmes, Edward C., Patterson, Randen L., van Rossum, Damian B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527991/
https://ncbi.nlm.nih.gov/pubmed/18765810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803860105
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