Reciprocal relationship between expression of hypoxia inducible factor 1α (HIF-1α) and the pro-apoptotic protein Bid in ex vivo colorectal cancer

Hypoxia inducible factor 1 (HIF-1) represses the transcription of pro-apoptotic bid in colorectal cancer cells in vitro. To assess the clinical relevance of this observation, HIF-1α and Bid were assessed in serial sections of 39 human colorectal adenocarcinomas by immunohistochemistry. In high HIF-1...

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Detalhes bibliográficos
Main Authors: Seenath, M M, Roberts, D, Cawthorne, C, Saunders, M P, Armstrong, G R, O'Dwyer, S T, Stratford, I J, Dive, C, Renehan, A G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527799/
https://ncbi.nlm.nih.gov/pubmed/18648372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604474
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