Ligand Activation of Peroxisome Proliferator–Activated Receptor β/δ (PPARβ/δ) Attenuates Carbon Tetrachloride Hepatotoxicity by Downregulating Proinflammatory Gene Expression

Peroxisome proliferator–activated receptor (PPAR) β/δ–null mice exhibit exacerbated hepatotoxicity in response to administration of carbon tetrachloride (CCl(4)). To determine whether ligand activation of the receptor protects against chemical toxicity in the liver, wild-type and PPARβ/δ-null mice w...

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Bibliographische Detailangaben
Hauptverfasser: Shan, Weiwei, Palkar, Prajakta S., Murray, Iain A., McDevitt, Emily I., Kennett, Mary J., Kang, Boo Hyon, Isom, Harriet C., Perdew, Gary H., Gonzalez, Frank J., Peters, Jeffrey M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2008
Schlagworte:
Systems Toxicology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527639/
https://ncbi.nlm.nih.gov/pubmed/18622026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfn142
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