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Activation of the p42 Mitogen-activated Protein Kinase Pathway Inhibits Cdc2 Activation and Entry into M-Phase in Cycling Xenopus Egg Extracts

We have added constitutively active MAP kinase/ERK kinase (MEK), an activator of the mitogen-activated protein kinase (MAPK) signaling pathway, to cycling Xenopus egg extracts at various times during the cell cycle. p42MAPK activation during entry into M-phase arrested the cell cycle in metaphase, a...

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Udgivet i:Mol Biol Cell
Principais autores: Bitangcol, John C., Chau, Andrew S.-S., Stadnick, Ellamae, Lohka, Manfred J., Dicken, Bryan, Shibuya, Ellen K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Cell Biology 1998
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC25274/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9450967/
https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.9.2.451
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