Delayed administration of a matrix metalloproteinase inhibitor limits progressive brain injury after hypoxia-ischemia in the neonatal rat

BACKGROUND: Hypoxia-ischemia (H-I) can produce widespread neurodegeneration and deep cerebral white matter injury in the neonate. Resident microglia and invading leukocytes promote lesion progression by releasing reactive oxygen species, proteases and other pro-inflammatory mediators. After injury,...

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Autores principales: Leonardo, Christopher C, Eakin, Autumn K, Ajmo, Joanne M, Collier, Lisa A, Pennypacker, Keith R, Strongin, Alex Y, Gottschall, Paul E
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2008
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Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527306/
https://ncbi.nlm.nih.gov/pubmed/18694515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-5-34
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