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Mechanistic and Structural Analyses of the Roles of Arg409 and Asp402 in the Reaction of the Flavoprotein Nitroalkane Oxidase

The flavoprotein nitroalkane oxidase (NAO) catalyzes the oxidation of primary and secondary nitroalkanes to the corresponding aldehydes and ketones. The enzyme is a homolog of acyl-CoA dehydrogenase. Asp402 in NAO has been proposed to be the active site base responsible for removing the substrate pr...

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Autori principali: Fitzpatrick, Paul F., Bozinovski, Dragana M., Héroux, Annie, Shaw, Patrick G., Valley, Michael P., Orville, Allen M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2526231/
https://ncbi.nlm.nih.gov/pubmed/17994768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi701557k
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