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Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4.

Using Vero cells transformed with the wild-type gene for ICP4 as the permissive host cell, we isolated herpes simplex virus type 1 (HSV-1) mutants containing deletions in both copies of the ICP4 gene. The mutants, d120 and d202, contained deletions of 4.1 and 0.5 kilobases, respectively, in each cop...

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Udgivet i:J Virol
Principais autores: DeLuca, N A, McCarthy, A M, Schaffer, P A
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1985
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC252613/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2997476/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.56.2.558-570.1985
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