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Transanal Delivery of Angiotensin Converting Enzyme Inhibitor Prevents Colonic Fibrosis in a Mouse Colitis Model: Development of a unique mode of treatment

BACKGROUND: We have previously shown that angiotensin converting enzyme-inhibitor (ACE-I) improved colonic inflammation and apoptosis in a dextran sodium sulfate (DSS)-induced colitis model. This study attempted to determine whether ACE-I could prevent the development of colonic fibrosis. METHODS: C...

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Bibliografiske detaljer
Main Authors: Koga, Hiroyuki, Yang, Hua, Adler, Jeremy, Zimmermann, Ellen M., Teitelbaum, Daniel H
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2526058/
https://ncbi.nlm.nih.gov/pubmed/18656634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2008.03.043
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