Human Aging Magnifies Genetic Effects on Executive Functioning and Working Memory

We demonstrate that common genetic polymorphisms contribute to the increasing heterogeneity of cognitive functioning in old age. We assess two common Val/Met polymorphisms, one affecting the Catechol-O-Methyltransferase (COMT) enzyme, which degrades dopamine (DA) in prefrontal cortex (PFC), and the...

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Hlavní autoři: Nagel, Irene E., Chicherio, Christian, Li, Shu-Chen, von Oertzen, Timo, Sander, Thomas, Villringer, Arno, Heekeren, Hauke R., Bäckman, Lars, Lindenberger, Ulman
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Research Foundation 2008
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2525971/
https://ncbi.nlm.nih.gov/pubmed/18958202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/neuro.09.001.2008
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