Human Aging Magnifies Genetic Effects on Executive Functioning and Working Memory

We demonstrate that common genetic polymorphisms contribute to the increasing heterogeneity of cognitive functioning in old age. We assess two common Val/Met polymorphisms, one affecting the Catechol-O-Methyltransferase (COMT) enzyme, which degrades dopamine (DA) in prefrontal cortex (PFC), and the...

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Detalhes bibliográficos
Main Authors: Nagel, Irene E., Chicherio, Christian, Li, Shu-Chen, von Oertzen, Timo, Sander, Thomas, Villringer, Arno, Heekeren, Hauke R., Bäckman, Lars, Lindenberger, Ulman
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Research Foundation 2008
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2525971/
https://ncbi.nlm.nih.gov/pubmed/18958202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/neuro.09.001.2008
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