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Partial activity is seen with many substitutions of highly conserved active site residues in human Pseudouridine synthase 1
Pseudouridine synthase 1 (Pus1p) is an enzyme that converts uridine to Pseudouridine (Ψ) in tRNA and other RNAs in eukaryotes. The active site of Pus1p is composed of stretches of amino acids that are highly conserved and it is hypothesized that mutation of select residues would impair the enzyme�...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Cold Spring Harbor Laboratory Press
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2525951/ https://ncbi.nlm.nih.gov/pubmed/18648068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.984508 |
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