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Perifosine induces differentiation and cell death in prostate cancer cells
We analyzed the mechanism of action for perifosine (D-21266) a new synthetic alkylphospholipid Akt inhibitor using LNCaP and PC-3 prostate cancer cells. Perifosine treatment of PC-3 cells resulted in cytostatic and cytotoxic effects. Cytostatic effects were characterized by cell growth arrest, cell...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2525810/ https://ncbi.nlm.nih.gov/pubmed/18395973 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2008.02.060 |
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