Inhibition of Endosome Fusion by Wortmannin Persists in the Presence of Activated rab5

Rab5-dependent endosome fusion is sensitive to the phosphoinositide 3-kinase inhibitor, wortmannin. It has been proposed that phosphoinositide 3-kinase activity may be required for activation of rab5 by influencing its nucleotide cycle such as to promote its active GTP state. In this report we demon...

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Pubblicato in:	Mol Biol Cell
Autori principali:	Jones, Arwyn T., Mills, Ian G., Scheidig, Axel J., Alexandrov, Kirill, Clague, Michael J.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Cell Biology 1998
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC25257/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9450958/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.9.2.323
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