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Assembling OX40 Aptamers on a Molecular Scaffold to Create a Receptor-Activating Aptamer
We show that a molecular scaffold can be utilized to convert a receptor binding aptamer into a receptor agonist. Many receptors (including tumor necrosis receptor family members) are activated when they are multimerized on the cell surface. Molecular scaffolds have been utilized to assemble multiple...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2525512/ https://ncbi.nlm.nih.gov/pubmed/18635004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2008.05.016 |
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