Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff.

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• Adenovirus type 5 early region 1b gene product is required for efficient shutoff of host protein synthesis.
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  出版: (1984)
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• Adenoviral early region 4 is required for efficient viral DNA replication and for late gene expression.
  由: Weinberg, D H, et al.
  出版: (1986)
• Topoisomerase I and II cleavage of adenovirus DNA in vivo: both topoisomerase activities appear to be required for adenovirus DNA replication.
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• Deletion of the gene encoding the adenovirus 5 early region 1b 21,000-molecular-weight polypeptide leads to degradation of viral and host cell DNA.
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