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Alphavirus neurovirulence: monoclonal antibodies discriminating wild-type from neuroadapted Sindbis virus.

Wild-type Sindbis virus strain AR339 (SV) and a neurovirulent mutant (NSV), derived by neonatal and weanling mouse brain passage, both cause acute fatal encephalitis in neonatal mice, but NSV alone kills adult mice. NSV cannot be distinguished from SV by immune sera or simple biochemical tests. To l...

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Udgivet i:J Virol
Principais autores: Stanley, J, Cooper, S J, Griffin, D E
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1985
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC252488/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2411947/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.56.1.110-119.1985
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