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Nonpolar substitution at C-terminus of the prion protein, a mimic of GPI anchor, partially impairs amyloid fibrils formation

In contrast to most amyloidogenic proteins or peptides that do not contain any significant post-translational modifications, the prion protein (PrP) is modified with either one or two polysaccharides and a GPI anchor which attaches PrP to the plasma membrane. Like other amyloidogenic proteins, howev...

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Detalhes bibliográficos
Main Authors: Breydo, Leonid, Sun, Ying, Makarava, Natallia, Lee, Cheng-I, Novitskaia, Vera, Bocharova, Olga, Kao, Joseph P.Y., Baskakov, Ilia V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2522369/
https://ncbi.nlm.nih.gov/pubmed/17223707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi061923v
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