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Inhibition of Monometalated Methionine Aminopeptidase: Inhibitor Discovery and Crystallographic Analysis

Two divalent metal ions are commonly seen in the active site cavity of methionine aminopeptidase, and at least one of the metal ions is directly involved in catalysis. Although ample structural and functional information is available for dimetalated enzyme, methionine aminopeptidase likely functions...

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Hlavní autoři: Huang, Min, Xie, Sheng-Xue, Ma, Ze-Qiang, Huang, Qing-Qing, Nan, Fa-Jun, Ye, Qi-Zhuang
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2522305/
https://ncbi.nlm.nih.gov/pubmed/17948983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm700930k
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