Priming with EGFR tyrosine kinase inhibitor and EGF sensitizes ovarian cancer cells to respond to chemotherapeutical drugs

Over-expression of EGFR, as in most cases of ovarian cancer, is associated with advanced-stage disease and poor prognosis. Activation of EGFR signaling pathway is involved in increased cell proliferation, angiogenesis, metastasis, and decreased apoptosis. Tyrosine kinase activity is essential for si...

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Hlavní autoři: Cao, Cong, Lu, Shan, Sowa, Alex, Kivlin, Rebecca, Amaral, Ashley, Chu, Wenming, Yang, Hui, Di, Wen, Wan, Yinsheng
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519958/
https://ncbi.nlm.nih.gov/pubmed/18400375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2008.02.062
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