Kinetic and Structural Insight into the Mechanism of BphD, a C-C Bond Hydrolase from the Biphenyl Degradation Pathway

Kinetic and structural analyses of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA) hydrolase from Burkholderia xenovorans LB400 (BphD(LB400)) provide insight into the catalytic mechanism of this unusual serine hydrolase. Single turnover stopped-flow analysis at 25 °C showed that the enzyme rap...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Horsman, Geoff P., Ke, Jiyuan, Dai, Shaodong, Seah, Stephen Y. K., Bolin, Jeffrey T., Eltis, Lindsay D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2006
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519953/
https://ncbi.nlm.nih.gov/pubmed/16964968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi0611098
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