Determination of Local Tissue Concentrations of Bupivacaine Released from Biodegradable Microspheres and the Effect of Vasoactive Compounds on Bupivacaine Tissue Clearance Studied by Microdialysis Sampling

PURPOSE: Incorporation of bupivacaine, a short acting local analgesic, into injectable microspheres provides a long acting formulation. Co-incorporation of dexamethasone into the microspheres results in extended activity. The purpose of this study is to compare tissue concentrations of bupivacaine r...

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Main Authors: McDonald, Sarah, Faibushevich, Alexander A., Garnick, Susan, Mclaughlin, Kieran, Lunte, Craig
Format: Artigo
Language:Inglês
Published: 2002
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519825/
https://ncbi.nlm.nih.gov/pubmed/12458682
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