Leishmania Adaptor Protein-1 Subunits Are Required for Normal Lysosome Traffic, Flagellum Biogenesis, Lipid Homeostasis, and Adaptation to Temperatures Encountered in the Mammalian Host

The adaptor protein-1 (AP-1) complex is involved in membrane transport between the Golgi apparatus and endosomes. In the protozoan parasite Leishmania mexicana mexicana, the AP-1 μ1 and σ1 subunits are not required for growth at 27°C but are essential for infectivity in the mammalian host. In this s...

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Bibliografiska uppgifter
Huvudupphovsmän: Vince, James E., Tull, Dedreia L., Spurck, Timothy, Derby, Merran C., McFadden, Geoffrey I., Gleeson, Paul A., Gokool, Suzanne, McConville, Malcolm J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 2008
Ämnen:
Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519780/
https://ncbi.nlm.nih.gov/pubmed/18515754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.00090-08
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