Removal of Oxidative DNA Damage via FEN1-Dependent Long-Patch Base Excision Repair in Human Cell Mitochondria

Repair of oxidative DNA damage in mitochondria was thought limited to short-patch base excision repair (SP-BER) replacing a single nucleotide. However, certain oxidative lesions cannot be processed by SP-BER. Here we report that 2-deoxyribonolactone (dL), a major type of oxidized abasic site, inhibi...

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Main Authors: Liu, Pingfang, Qian, Limin, Sung, Jung-Suk, de Souza-Pinto, Nadja C., Zheng, Li, Bogenhagen, Daniel F., Bohr, Vilhelm A., Wilson, David M., Shen, Binghui, Demple, Bruce
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519700/
https://ncbi.nlm.nih.gov/pubmed/18541666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00457-08
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