Loss of the N-Linked Glycan at Residue 173 of Human Parainfluenza Virus Type 1 Hemagglutinin-Neuraminidase Exposes a Second Receptor-Binding Site

BCX 2798 (4-azido-5-isobutyrylamino-2,3-didehydro-2,3,4,5-tetradeoxy-d-glycero-d-galacto-2-nonulopyranosic acid) effectively inhibited the activities of the hemagglutinin-neuraminidase (HN) of human parainfluenza viruses (hPIV) in vitro and protected mice from lethal infection with a recombinant Sen...

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Bibliographic Details
Main Authors: Alymova, Irina V., Taylor, Garry, Mishin, Vasiliy P., Watanabe, Makiko, Murti, K. Gopal, Boyd, Kelli, Chand, Pooran, Babu, Y. Sudhakara, Portner, Allen
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519627/
https://ncbi.nlm.nih.gov/pubmed/18579600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00474-08
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