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Proteome-wide Profiling of Isoniazid Targets in Mycobacterium tuberculosis
Isoniazid (INH) is an essential drug used to treat tuberculosis. The mycobactericidal agents are INH adducts (INH-NAD(P)) of the pyridine nucleotide coenzymes, which are generated in vivo after INH activation, and which bind to, and inhibit, essential enzymes. The NADH-dependent enoyl-ACP reductase...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2519606/ https://ncbi.nlm.nih.gov/pubmed/17115689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi061874m |
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